Prof. Dr. Mona Ahmed Abdel-Rahman Ali

Main content

Mona stayed with us as a postdoctoral scientist from December 2007 to August 2008, from August to October 2009, in June/July 2010 and from July to September 2015.

Currently at:

Assiut University, Egypt

Mona Ahmed Abdel-Rahman Ali
Mona Ahmed Abdel-Rahman Ali

Publications

Design, synthesis and cytotoxic activity of water-soluble quinones with dibromo-p-benzoquinone cores and amino oligo(ethylene glycol) side chains against MCF-7 breast cancer cells
Leon F. Scherz, Engy A. Abdel-Rahman, Sameh S. Ali, A. Dieter Schlüter and Mona A. Abdel-Rahman
MedChemComm, vol. 8: no. 3, pp. 662-672, Cambridge: Royal Society of Chemistry, 2017.
Solvatochromism of dye-labeled dendronized polymers of generation numbers 1-4: comparison to dendrimers
Chiara Gstrein, Baozhong Zhang, Mona A. Abdel-Rahman, Oscar Bertran, Carlos Alemán, Gerhard Wegner and A. Dieter Schlüter
Chemical Science, vol. 7, pp. 4644-4652, Cambridge: Royal Society of Chemistry, 2016.

Two series of dendronized polymers (DPs) of generations g = 1-4 with different levels of dendritic substitution (low and high) and a solvatochromic probe at g = 1 level are used to study their swelling behavior in a collection of solvents largely differing in polarity as indicated by the Kamlet-Taft parameters. This is done by measuring the UV-Vis spectra of all samples in all solvents and determining the longest wavelength absorptions (λmax). The λmax values fall into a range defined by the extreme situations, when the solvatochromic probe is either fully surrounded by solvent or completely shielded against it. The former situation is achieved in a model compound and the latter situation is believed to be reached when in a poor solvent the dendritic shell around the backbone is fully collapsed. We observe that solvent penetration into the interior of the DPs decreases with increasing g and does so faster for the more highly dendritically substituted series than for the less highly substituted one. Interestingly, the swelling of the more highly substituted DP series already at the g = 4 level has decreased to approximately 20% of that at the g = 1 level which supports an earlier proposal that high g DPs can be viewed as nano-sized molecular objects. Furthermore, when comparing these two DP series with a g = 1-6 series of dendrimers investigated by Fréchet et al. it becomes evident that even the less substituted series of DPs is much less responsive to solvent changes as assessed by the solvatochromic probe than the dendrimers, suggesting the branches around the (polymeric) core in DPs to be more densely packed compared to those in dendrimers, thus, establishing a key difference between these two dendritic macromolecules.

!!! Dieses Dokument stammt aus dem ETH Web-Archiv und wird nicht mehr gepflegt !!!
!!! This document is stored in the ETH Web archive and is no longer maintained !!!
JavaScript has been disabled in your browser